PhD Defence Aurore C.M-J. Delvenne

Keywords: Alzheimer’s disease, biomarkers, proteomics, choroid plexus
 

"CSF Proteomic Signatures in Alzheimer's Disease Across Amyloid and Tau Biomarker Subgroups"

As life expectancy rises, Alzheimer’s disease (AD) is expected to become a major healthcare challenge, highlighting the urgent need for effective treatments. However, progress is hindered by significant gaps in understanding the disease’s pathophysiology. This thesis aimed to enhance our knowledge of the mechanisms underlying AD and related biomarker-based subgroups, such as Suspected Non-Alzheimer’s Pathophysiology (SNAP). A key method for studying AD’s pathophysiology is analyzing protein levels in cerebrospinal fluid and brain tissue, known as proteomics, which was the approach used in this thesis. This thesis investigated the underlying pathophysiological processes implicated in SNAP, as well as its diagnostic and prognostic importance. This thesis also explored the pathophysiology of predementia AD, by more specifically focussing on the processes linked to various AD neurodegeneration markers and the role of the choroid plexus in AD development. The findings from this thesis provide crucial insights into the complex molecular processes underlying AD and SNAP, with implications for future proteomic research, clinical practice, and the development of future treatments.

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