Universiteit Maastricht

Personal profile page

prof dr M.J. Post

MD, PhD

Positions

Professor of Vascular Physiology

Chair of Physiology

E-mail:
prof dr M.J.  Post

Expertise

Physiology

vascular biology

skeletal muscle tissue engineering

vascular tissue engineering

Professional Career History

1982    MD                             Utrecht University, Utrecht , The Netherlands

1989    PhD, Pharmacology      Utrecht University, Utrecht, The Netherlands

2004-   various UM management courses

 

4.         Professional appointments

1984-1985    Instructor in Pharmacology

1989-1997    Senior Investigator at Interuniversity Cardiology Institute of the Netherlands (equivalent to Associate Professor title in USA)

1995-1997      Visiting scientist Harvard Medical School, at Beth Israel Deaconess Medical Center

1997-1998      Instructor in Medicine Harvard Medical School

1998-2001    Assistant Professor of Medicine, Harvard Medical School

2001-2002    Associate Professor of Medicine and of Physiology, Dartmouth Medical School

2002 -2010   Visiting professor in Medicine and in Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA

2002 -2010   Professor of Angiogenesis in Tissue Engineering (HL1) Technical University Eindhoven, The Netherlands

2002 - now   Professor of Vascular Physiology and Tissue Engineering (HL2), Maastricht University, The Netherlands

2004 - 2011  Chairman of Physiology Department (HL2), Maastricht University, The Netherlands

2005 - 2010  acting Chairman of Biophysics, Maastricht University, The Netherlands

2006 - 2011  Vice dean BMT, Technical University Eindhoven, The Netherlands

2011-2012    acting scientific director CARIM, FHML, Maastricht University

2012-now     Chairman of Physiology Department, Maastricht University

 

Research Profile

My main interest is Vascular Biology, particularly fundamental processes such as vascular patterning, neovascularization, endothelial and smooth muscle cell function and restenosis. As a translational arm of the research, we develop and test novel biomaterials that are suitable for arterial grafting for bypass surgery of vascular access surgery (AV shunt), providing in situ tissue engineering. The response and in vivo remodelling of these grafts provide great insight into the role of biochemical and biomechanical cues in vascular biology.

In addition, we are engaged into early diagnosis of neovascularization by means of molecular imaging. We have identified 4 novel targets for molecular imaging that we are testing in SPECT imaging of cardiovascular models exhibiting neovascularization.

Therapeutic neovascularization will likely be dependent on effective slow release, local administration of potent biologicals. Drug release polymers are currently tested for that purpose.

Finally, I became involved in a completely different field of tissue engineering: skeletal muscle tissue engineering in order to create cultured consumption meat. This technology offers great opportunities for future meat production if culture efficiency and tissue mimicry can be achieved in a cost-effective manner.

 

Research Projects

iVALVE (PI). In this consortium we develop and test new materials for arterial grafting. It is a collaboration with TU/e, Suprapolix, SymoChem, Philips, and UMCU. We have developed an electrosensitive polymer that facilitates ingrowth, cell alignment and collagen production. We also test grafts from novel PLC-based materials in a rat aorta interposition or bypass graft model.

PENT (PI). In this consortium together with TU/e, DSM, UMUC and LUMC, we develop and tested novel agent and delivery methods to enhance neovascularization.

TeRM (PI). TeRM is a national consortium of several universities and companies with the aim to develop novel tissue engineering solutions for musculoskeletal and cardiovascular defects. Autologous cells on biomaterials are being used for this purpose. Our group tested grafts in large and small animal models of interposition grafts and AV shunts. In addition, we developed novel assays for thrombogenicity of endothelial layers and on-line non-destructive collagen synthesis. Smooth muscle cell thrombogenicity and smooth muscle cell relaxation in the setting of uremia are also being investigated

EMINENCE (coordinator/PI). This is also a national consortium focussing on early diagnosis of neovascularization using sophisticated MRI acquisition and image analysis, but also novel molecular targets and visualization with SPECT.

The Hamburger project is a philantropy financed program which aims to develop consumption meat from bovine skeletal muscle stem cells. In the spring of 2013 we plan to present the world's first labgrown hamburger.

 

Publications

1          Wolters M, van Hoof RH, Wagenaar A, Douma K, van Zandvoort MA, Hackeng TH, Post MJ, Backes WH, Kooi ME. Mri artifacts in the ferric chloride thrombus animal model: An alternative solution: Preventing mri artifacts after thrombus induction with a non-ferromagnetic lewis acid.Journal of thrombosis and haemostasis : JTH. 2013;11:1766-1769

2.         Wolters M, Mohades SG, Hackeng TM, Post MJ, Kooi ME, Backes WH. Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy. Invest Radiol. 2013;48:341-350

3.         van den Akker NM, Post MJ. Career switch for ec-cfu to modelling. Cardiovasc Res. 2013;100:175-177

4.         Smulders MW, Kietselaer BL, Das M, Wildberger JE, Crijns HJ, Veenstra LF, Brunner-La Rocca HP, van Dieijen-Visser MP, Mingels AM, Dagnelie PC, Post MJ, Gorgels AP, van Asselt AD, Vogel G, Schalla S, Kim RJ, Bekkers SC. The role of cardiovascular magnetic resonance imaging and computed tomography angiography in suspected non-st-elevation myocardial infarction patients: Design and rationale of the cardiovascular magnetic resonance imaging and computed tomography angiography (carmenta) trial. American heart journal. 2013;166:968-975

5.         Rahimi N, Swennen G, Verbruggen S, Scibiorek M, Molin DG, Post MJ. Short stimulation of electro-responsive paa/fibrin hydrogel induces collagen production. Tissue Eng Part C Methods. 2013

6.         Rademakers T, Douma K, Hackeng TM, Post MJ, Sluimer JC, Daemen MJ, Biessen EA, Heeneman S, van Zandvoort MA. Plaque-associated vasa vasorum in aged apolipoprotein e-deficient mice exhibit proatherogenic functional features in vivo. Arterioscler Thromb Vasc Biol. 2013;33:249-256

7.         Post MJ, Rahimi N, Caolo V. Update on vascularization in tissue engineering. Regen Med. 2013;8:759-770

8.         Post MJ, Breewood HE, van Essen AL. Cultured beef: Current status and challenges. Food Science & Technology. 2013;27:4

9.         Post MJ. Cultured beef: Medical technology to produce food. Journal of the science of food and agriculture. 2013

10.       Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MP, Donners MM. Anti-inflammatory m2, but not pro-inflammatory m1 macrophages promote angiogenesis in vivo. Angiogenesis. 2013

11.       Jetten N, Donners MM, Wagenaar A, Cleutjens JP, van Rooijen N, de Winther MP, Post MJ. Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model. PLoS One. 2013;8:e68811

12.       Ghosh M, van den Akker NM, Wijnands KA, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DG, van Zandvoort MA. Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLoS One. 2013;8:e75331

13.       Geenen IL, Verbruggen S, Molin DG, Spronk HM, Maessen JG, Meesters B, Schurink GW, Post MJ. Phenotypic fitness of primary endothelial cells cultured from patients with high cardiovascular risk or chronic kidney disease for vascular tissue engineering. Tissue Eng Part A. 2013

14.       Wolters M, Oostendorp M, Coolen BF, Post MJ, Janssen JM, Strijkers GJ, Kooi ME, Nicolay K, Backes WH. Efficacy of positive contrast imaging techniques for molecular mri of tumor angiogenesis. Contrast media & molecular imaging. 2012;7:130-139

15.       van den Akker NM, Kolk FF, Jeukens F, Verbruggen S, Gagliardi M, Dullens S, Heschel I, Post MJ, Molin DG, Waltenberger J. Vascular potency of sus scrofa bone marrow-derived mesenchymal stem cells: A progenitor source of medial but not endothelial cells. Tissue engineering. Part A. 2012;18:828-839

16.       Rahimi N, Molin DG, Cleij TJ, van Zandvoort MA, Post MJ. Electrosensitive polyacrylic acid/fibrin hydrogel facilitates cell seeding and alignment. Biomacromolecules. 2012;13:1448-1457

17.       Post MJ. Cultured meat from stem cells: Challenges and prospects. Meat Sci. 2012;92:297-301

18.       Post MJ. Remember what i told you about therapeutic arteriogenesis, 11 years ago? Cardiovasc Res. 2012

19.       Jaspers K, Slenter JM, Leiner T, Wagenaar A, Post MJ, Backes WH. Automated multiscale vessel analysis for the quantification of mr angiography of peripheral arteriogenesis. J Magn Reson Imaging. 2012;35:379-386

20.       Geenen IL, Post MJ, Molin DG, Schurink GW, Maessen JG, R VO, Ten Cate H, Spronk HM. Coagulation on endothelial cells: The underexposed part of virchow's triad. Thrombosis and haemostasis. 2012;108

21.       Geenen IL, Molin DG, van den Akker NM, Jeukens F, Spronk HM, Schurink GW, Post MJ. Endothelial cells (ecs) for vascular tissue engineering: Venous ecs are less thrombogenic than arterial ecs. Journal of tissue engineering and regenerative medicine. 2012

22.       Caolo V, Molin DG, Post MJ. Notch regulation of hematopoiesis, endothelial precursor cells, and blood vessel formation: Orchestrating the vasculature. Stem Cells International. 2012;2012:805602

23.       van den Wijngaard JP, Schulten H, van Horssen P, Ter Wee RD, Siebes M, Post MJ, Spaan JA. Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone. Am J Physiol Heart Circ Physiol. 2011;300:H1930-1937

24.       Oostendorp M, de Vries EE, Slenter JM, Peutz-Kootstra CJ, Snoeijs MG, Post MJ, van Heurn LW, Backes WH. Mri of renal oxygenation and function after normothermic ischemia-reperfusion injury. NMR Biomed. 2011;24:194-200

25.       Langelaan ML, Boonen KJ, Rosaria-Chak KY, van der Schaft DW, Post MJ, Baaijens FP. Advanced maturation by electrical stimulation: Differences in response between c2c12 and primary muscle progenitor cells. Journal of tissue engineering and regenerative medicine. 2011;5:529-539

26.       Jaspers K, Versluis B, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. Mr angiography of collateral arteries in a hind limb ischemia model: Comparison between blood pool agent gadomer and small contrast agent gd-dtpa. PLoS One. 2011;6:e16159

27.       Caolo V, Schulten HM, Zhuang ZW, Murakami M, Wagenaar A, Verbruggen S, Molin DG, Post MJ. Soluble jagged-1 inhibits neointima formation by attenuating notch-herp2 signaling. Arterioscler Thromb Vasc Biol. 2011;31:1059-1065

28.       Boonen KJ, van der Schaft DW, Baaijens FP, Post MJ. Interaction between electrical stimulation, protein coating and matrix elasticity: A complex effect on muscle fibre maturation. Journal of tissue engineering and regenerative medicine. 2011;5:60-68

29.       Oostendorp M, Douma K, Wagenaar A, Slenter JM, Hackeng TM, van Zandvoort MA, Post MJ, Backes WH. Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction. Circulation. 2010;121:775-783

30.       Oostendorp M, Douma K, Hackeng TM, van Zandvoort MA, Post MJ, Backes WH. Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging. Contrast media & molecular imaging. 2010;5:9-17

31.       Oostendorp M, Douma K, Hackeng TM, Post MJ, van Zandvoort MA, Backes WH. Gadolinium-labeled quantum dots for molecular magnetic resonance imaging: R1 versus r2 mapping. Magn Reson Med. 2010;64:291-298

32.       Molin DG, van den Akker NM, Post MJ. 'Lox on neovascularization': Leukotrienes as mediators in endothelial biology. Cardiovasc Res. 2010;86:6-8

33.       Langelaan ML, Boonen KJ, Polak RB, Baaijens FP, Post MJ, van der Schaft DW. Meet the new meat: Tissue engineered skeletal muscle. Trends Food Sci Technol. 2010;21:7

34.       Jaspers K, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. Optimized pharmacokinetic modeling for the detection of perfusion differences in skeletal muscle with dce-mri: Effect of contrast agent size. Medical physics. 2010;37:5746-5755

35.       Douma K, Oostendorp M, Slaaf DW, Post MJ, Backes WH, van Zandvoort MA. Evaluation of magnetic resonance vessel size imaging by two-photon laser scanning microscopy. Magn Reson Med. 2010;63:930-939

36.       Donners MM, Wolfs IM, Olieslagers S, Mohammadi-Motahhari Z, Tchaikovski V, Heeneman S, van Buul JD, Caolo V, Molin DG, Post MJ, Waltenberger J. A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. Arterioscler Thromb Vasc Biol. 2010;30:2188-2195

37.       Caolo V, van den Akker NM, Verbruggen S, Donners MM, Swennen G, Schulten H, Waltenberger J, Post MJ, Molin DG. Feed-forward signaling by membrane bound ligand receptor circuit: The case of notch-delta like 4 in endothelial cells. The Journal of biological chemistry. 2010

38.       Boonen KJ, Langelaan ML, Polak RB, van der Schaft DW, Baaijens FP, Post MJ. Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering. Journal of biomechanics. 2010;43:1514-1521

39.       Pullens RA, Stekelenburg M, Baaijens FP, Post MJ. The influence of endothelial cells on the ecm composition of 3d engineered cardiovascular constructs. Journal of tissue engineering and regenerative medicine. 2009;3:11-18

40.       Oostendorp M, Post MJ, Backes WH. Vessel growth and function: Depiction with contrast-enhanced mr imaging. Radiology. 2009;251:317-335

41.       Lobbes MB, Miserus RJ, Heeneman S, Passos VL, Mutsaers PH, Debernardi N, Misselwitz B, Post M, Daemen MJ, van Engelshoven JM, Leiner T, Kooi ME. Atherosclerosis: Contrast-enhanced mr imaging of vessel wall in rabbit model--comparison of gadofosveset and gadopentetate dimeglumine. Radiology. 2009;250:682-691

42.       Jaspers K, Aerts HJ, Leiner T, Oostendorp M, van Riel NA, Post MJ, Backes WH. Reliability of pharmacokinetic parameters: Small vs. Medium-sized contrast agents. Magn Reson Med. 2009;62:779-787

43.       Douma K, Prinzen L, Slaaf DW, Reutelingsperger CP, Biessen EA, Hackeng TM, Post MJ, van Zandvoort MA. Nanoparticles for optical molecular imaging of atherosclerosis. Small (Weinheim an der Bergstrasse, Germany). 2009

44.       Boonen KJ, Rosaria-Chak KY, Baaijens FP, van der Schaft DW, Post MJ. Essential environmental cues from the satellite cell niche: Optimizing proliferation and differentiation. American journal of physiology. Cell physiology. 2009;296:C1338-1345

45.       van Golde JM, Ruiter MS, Schaper NC, Voo S, Waltenberger J, Backes WH, Post MJ, Huijberts MS. Impaired collateral recruitment and outward remodeling in experimental diabetes. Diabetes. 2008;57:2818-2823

46.       Oostendorp M, Douma K, Hackeng TM, Dirksen A, Post MJ, van Zandvoort MA, Backes WH. Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cngr-labeled paramagnetic quantum dots. Cancer Res. 2008;68:7676-7683

47.       Molin DG, van den Akker NM, Post MJ. Affirmative action of osteopontin on endothelial progenitors. Arterioscler Thromb Vasc Biol. 2008;28:2099-2100

48.       Boonen KJ, Post MJ. The muscle stem cell niche: Regulation of satellite cells during regeneration. Tissue engineering. Part B, Reviews. 2008;14:419-431

49.       Molin D, Post MJ. Therapeutic angiogenesis in the heart: Protect and serve. Curr Opin Pharmacol. 2007;7:158-163

50.       de Lussanet QG, van Golde JC, Beets-Tan RG, Post MJ, Huijberts MS, Schaper NC, Kessels AG, van Engelshoven JM, Backes WH. Dynamic contrast-enhanced mri of muscle perfusion combined with mr angiography of collateral artery growth in a femoral artery ligation model. NMR Biomed. 2007

51.       Radke PW, Heinl-Green A, Frass OM, Post MJ, Sato K, Geddes DM, Alton EW. Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies. Endothelium. 2006;13:25-33

52.       Post MJ, Waltenberger J. Ace inhibitors and statins for bone marrow failure following myocardial infarction? Cardiovasc Res. 2006;70:1-2

53.       Post MJ, Sato K, Murakami M, Bao J, Tirziu D, Pearlman JD, Simons M. Adenoviral pr39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Am J Physiol Regul Integr Comp Physiol. 2006;290:R494-500

54.       Molin DG, Post MJ. Do intrinsic arterial wall features determine atherosclerosis susceptibility? Cardiovasc Res. 2006;72:3-4

55.       de Lussanet QG, van Golde JC, Beets-Tan RG, de Haan MW, Zaar DV, Post MJ, Huijberts MS, Schaper NC, van Engelshoven JM, Backes WH. Magnetic resonance angiography of collateral vessel growth in a rabbit femoral artery ligation model. NMR Biomed. 2006;19:77-83

56.       Buehler A, van Zandvoort MA, Stelt BJ, Hackeng TM, Schrans-Stassen BH, Bennaghmouch A, Hofstra L, Cleutjens JP, Duijvestijn A, Smeets MB, de Kleijn DP, Post MJ, de Muinck ED. Cngr: A novel homing sequence for cd13/apn targeted molecular imaging of murine cardiac angiogenesis in vivo. Arterioscler Thromb Vasc Biol. 2006;26:2681-2687

57.       Schrans-Stassen BH, Lue H, Sonnemans DG, Bernhagen J, Post MJ. Stimulation of vascular smooth muscle cell migration by macrophage migration inhibitory factor. Antioxid Redox Signal. 2005;7:1211-1216

58.       Post M, Waltenberger J. Modulation of growth factor action in the cardiovascular system. Cardiovasc Res. 2005;65:547-549

59.       Laham RJ, Post M, Rezaee M, Donnell-Fink L, Wykrzykowska JJ, Lee SU, Baim DS, Sellke FW. Transendocardial and transepicardial intramyocardial fibroblast growth factor-2 administration: Myocardial and tissue distribution. Drug Metab Dispos. 2005;33:1101-1107

60.       Cao Y, Hong A, Schulten H, Post MJ. Update on therapeutic neovascularization. Cardiovasc Res. 2005;65:639-648

61.       Grinberg OY, Hou H, Grinberg SA, Moodie KL, Demidenko E, Friedman BJ, Post MJ, Swartz HM. Po2 and regional blood flow in a rabbit model of limb ischemia. Physiol Meas. 2004;25:659-670

62.       Degabriele NM, Griesenbach U, Sato K, Post MJ, Zhu J, Williams J, Jeffery PK, Geddes DM, Alton EW. Critical appraisal of the mouse model of myocardial infarction. Exp Physiol. 2004;89:497-505

63.       van Beusekom HM, Post MJ, Whelan DM, de Smet BJ, Duncker DJ, van der Giessen WJ. Metalloproteinase inhibition by batimastat does not reduce neointimal thickening in stented atherosclerotic porcine femoral arteries. Cardiovasc Radiat Med. 2003;4:186-191

64.       Storey P, Danias PG, Post M, Li W, Seoane PR, Harnish PP, Edelman RR, Prasad PV. Preliminary evaluation of evp 1001-1: A new cardiac-specific magnetic resonance contrast agent with kinetics suitable for steady-state imaging of the ischemic heart. Invest Radiol. 2003;38:642-652

65.       Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei LR, Clark C, Barchowsky A. Arsenic stimulates angiogenesis and tumorigenesis in vivo.Toxicol Sci. 2003;76:271-279

66.       Post MJ, Simons M. The rational phase of therapeutic angiogenesis. Minerva Cardioangiol. 2003;51:421-432

67.       Mandinov L, Mandinova A, Kyurkchiev S, Kyurkchiev D, Kehayov I, Kolev V, Soldi R, Bagala C, de Muinck ED, Lindner V, Post MJ, Simons M, Bellum S, Prudovsky I, Maciag T. Copper chelation represses the vascular response to injury. Proc Natl Acad Sci U S A. 2003;100:6700-6705

68.       Laham RJ, Rezaee M, Post M, Xu X, Sellke FW. Intrapericardial administration of basic fibroblast growth factor: Myocardial and tissue distribution and comparison with intracoronary and intravenous administration. Catheter Cardiovasc Interv. 2003;58:375-381

69.       Laham RJ, Li J, Tofukuji M, Post M, Simons M, Sellke FW. Spatial heterogeneity in vegf-induced vasodilation: Vegf dilates microvessels but not epicardial and systemic arteries and veins. Ann Vasc Surg. 2003;17:245-252

70.       Hughes GC, Post MJ, Simons M, Annex BH. Translational physiology: Porcine models of human coronary artery disease: Implications for preclinical trials of therapeutic angiogenesis. J Appl Physiol. 2003;94:1689-1701

71.       HajMohammadi S, Enjyoji K, Princivalle M, Christi P, Lech M, Beeler D, Rayburn H, Schwartz JJ, Barzegar S, de Agostini AI, Post MJ, Rosenberg RD, Shworak NW. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003;111:989-999

72.       Gaczynska M, Osmulski PA, Gao Y, Post MJ, Simons M. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry. 2003;42:8663-8670

73.       Cao R, Brakenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of pdgf-bb and fgf-2. Nat Med. 2003;9:604-613

74.       Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, Andrews NC, Simons M, Krieger M. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor sr-bi/apolipoprotein e double knockout mouse. Proc Natl Acad Sci U S A. 2003;100:7283-7288

75.       Zhuang ZW, Sato K, Mandinov L, Maciag T, Simons M, Post MJ. Effect of jagged and soluble on intimal hyperplasia in a rat carotid artery injury model. Circulation. 2002

76.       Skalak TC, Little CD, McIntire LV, Hirschi KK, Tranquillo RT, Post M, Ranieri J. Vascular assembly in engineered and natural tissues: Breakout session summary. Ann N Y Acad Sci. 2002;961:255-257

77.       Ruel M, Laham RJ, Parker JA, Post MJ, Ware JA, Simons M, Sellke FW. Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J Thorac Cardiovasc Surg. 2002;124:28-34

78.       Post MJ, Sato K, Mandrusov E, Simons M. Mode of administration determines if mcp-1 and fgf-2 promote arteriogenesis or angiogenesis in a rabbit model of hindlimb ischemia. Circulation. 2002

79.       Post MJ, Pawliuk R, Leboulch P, Arbuckle B, Palac RT, Beaver T, Kiorpes T, Spaltro J, Simons M. Intramyocardial slow release pdgf-bb dose dependently improves perfusion and function in a pig model of cardiac ischemia. Circulation. 2002

80.       Post MJ, Laham RJ, Kuntz RE, Novicki D, Simons M. The effect of intracoronary fibroblast growth factor-2 on restenosis after primary angioplasty or stent placement in a pig model of atherosclerosis. Clin Cardiol. 2002;25:271-278

81.       Post MJ, Bao J, Sato K, Simons M. Adenoviral pr-39 improves perfusion and function in a pig model of chronic myocardial ischemia.Circulation. 2002

82.       Post MJ. Angiogenesis: Initiation and maintenance. Ann N Y Acad Sci. 2002;961:249-250.

83.       Post M, Simons M. Adenoviral gene therapy with pr39 peptide in chronically ischemic myocardium. ENDOTHELIUM-YVERDON-. 2002;9

84.       Pearlman JD, Laham RJ, Post M, Leiner T, Simons M. Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. Curr Pharm Des. 2002;8:1467-1496

85.       Helisch A, Wagner S, Ziegelhoeffer T, Post MJ. Pr11 & pr39 protect against tissue necrosis in mouse ischemic hindlimb model. Circulation. 2002

86.       Braun A, Trigatti BL, Post MJ, Sato K, Simons M, Edelberg JM, Rosenberg RD, Schrenzel M, Krieger M. Loss of sr-bi expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein e-deficient mice. Circulation Research. 2002;90:270-276

87.       Wentzel JJ, Kloet J, Andhyiswara I, Oomen JA, Schuurbiers JC, de Smet BJ, Post MJ, de Kleijn D, Pasterkamp G, Borst C, Slager CJ, Krams R. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: Effect of matrix metalloproteinase inhibition. Circulation. 2001;104:91-96.

88.       Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andrian UH, Weitz JI. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001;21:1531-1537.

89.       Simons M, Post MJ. Coronary artery disease: Vascular endothelial growth factor and fibroblast growth factor. Curr Interv Cardiol Rep. 2001;3:185-191.

90.       Sato K, Wu T, Laham RJ, Johnson RB, Douglas P, Li J, Sellke FW, Bunting S, Simons M, Post MJ. Efficacy of intracoronary or intravenous vegf165 in a pig model of chronic myocardial ischemia. Journal of the American College of Cardiology. 2001;37:616-623

91.       Post MJ, Simons M. Gene therapy versus protein-based therapy: A matter of pharmacokinetics. Drug Discov Today. 2001;6:769-770.

92.       Post MJ, Laham R, Sellke FW, Simons M. Therapeutic angiogenesis in cardiology with protein formulations. Cardiovascular Research. 2001;49:522-531

93.       Pearlman JD, Gertz ZM, Wu Y, Simons M, Post MJ. Serial motion assessment by reference tracking (smart): Application to detection of local functional impact of chronic myocardial ischemia. J Comput Assist Tomogr. 2001;25:558-562.

94.       Laham RJMAPMJSF. Gene transfer to induce angiogenesis in myocardial and limb ischaemia. Expert Opinion on Biological Therapy. 2001;1:985-994

95.       Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post MJ. Pr-39 and pr-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated ikappabalpha degradation. Am J Physiol Heart Circ Physiol. 2001;281:H2612-2618.

96.       Bao J, Naimark W, Palasis M, Laham R, Simons M, Post MJ. Intramyocardial delivery of fgf2 in combination with radio frequency transmyocardial revascularization. Catheter Cardiovasc Interv. 2001;53:429-434.

97.       Wu Y, Post MJ, Datta R, Gao L, Pearlman JD. Identification of optimal parameters for first-pass cardiac mri perfusion measurement by receiver operating characteristic analysis. Circulation. 2000;Abstract

98.       Simons M, Laham RJ, Post M, Sellke FW. Therapeutic angiogenesis: Potential role of basic fibroblast growth factor in patients with severe ischaemic heart disease. BioDrugs. 2000;14:13-20

99.       Sato K, Laham RJ, Pearlman JD, Novicki D, Sellke FW, Simons M, Post MJ. Efficacy of intracoronary versus intravenous fgf-2 in a pig model of chronic myocardial ischemia.[in process citation]. Ann Thorac Surg. 2000;70:2113-2118

100.     Post MJ, Sato K, Kornowski R, Epstein SE, Leon MB, Baim D, Simons M, Laham RJ. Adenovirus mediated gene therapy through intramyocardial injections: Percutaneous intramyocardial versus surgical epicardial delivery. Cardiac and Vascular Regeneration. 2000;1:106-113

101.     Post MJ, Sato K, Bao J, Robert Pawliuk R, Leboulch P. In vivo role of paf and no in angiogenesis induced by fgf-2 and vegf165. Circulation. 2000;Abstract

102.     Post MJ, Moore P, Menahem N, Bao J, Virmani R, Kolodgi F, Corl D, Kuntz RE. Intravascular sonotherapy prevents intimal hyperplasia in a coronary stent pig model without long term adverse effects. Circulation. 2000;102

103.     Post MJ, Laham RJ, Sato K, Baim D. Adenovirus mediated gene therapy through intramyocardial injections: Percutaneous intramyocardial versus surgical epicardial delivery. Circulation. 2000;Abstract

104.     Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Sellke F, Carmeliet P, Simons M. Pr39, a peptide regulator of angiogenesis. Nat Med. 2000;6:49-55

105.     Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000;292:795-802

106.     Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M. Inhibition of ubiquitin-proteasome pathway-mediated i kappa b alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000;106:439-448

107.     de Smet BJ, de Kleijn D, Hanemaaijer R, Verheijen JH, Robertus L, van Der Helm YJ, Borst C, Post MJ. Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic yucatan micropig. Circulation. 2000;101:2962-2967

108.     Danias PG, Prasad PV, Storey E, Li W, Post MJ, Seoane P, Harnish P, Edelman RR. Magnetic resonance myocardial perfusion imaging in animals using a novel intracellular mn-based contrast agent. Circulation. 2000;Abstract

109.     Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R. Anti-angiogenic cues from vascular basement membrane collagen [in process citation]. Cancer Res. 2000;60:2520-2526

110.     Benzaquen LR, Nesto RW, Post MJ. Inhibition of mac formation by statins: A possible role for complement in acute coronary syndromes.CIrculation. 2000;Abstract

111.     Verheye S, Salame MY, Robinson KA, Post MJ, Carrozza JP, Jr., Baim DS, Sigwart U, King SB, 3rd, Chronos NA. Short- and long-term histopathologic evaluation of stenting using a self-expanding nitinol stent in pig carotid and iliac arteries [in process citation]. Catheter Cardiovasc Interv. 1999;48:316-323

112.     Laham RJ, Rezaee M, Post M, Sellke FW, Braeckman RA, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: Myocardial and tissue distribution. Drug Metab Dispos. 1999;27:821-826

113.     Garcia L, Baim DS, Post M, Simons M, Laham RJ. Therapeutic angiogenesis using endocardial approach to administration: Techniques and results. Current interventional cardiology reports. 1999;1:222

114.     van Leeuwen TG, Velema E, Pasterkamp G, Post MJ, Borst C. Saline flush during excimer laser angioplasty: Short and long term effects in the rabbit femoral artery. Lasers Surg Med. 1998;23:128-140

115.     Laham R, Rezaee M, Post M, Novicki M, Sellke F, Pearlman J, Hung D, Simons M. A single intrapericardial dose of basic fibroblast growth factor induces functional angiogenesis in a porcine model of chronic myocardial ischemia. Circulation. 1998;98:I-794

116.     Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ, Serruys PW. Shear stress in atherosclerosis, and vascular remodelling. Semin Interv Cardiol. 1998;3:39-44

117.     de Smet BJ, van der Zande J, van der Helm YJ, Kuntz RE, Borst C, Post MJ. The atherosclerotic yucatan animal model to study the arterial response after balloon angioplasty: The natural history of remodeling. Cardiovasc Res. 1998;39:224-232

118.     de Smet BJ, Pasterkamp G, van der Helm YJ, Borst C, Post MJ. The relation between de novo atherosclerosis remodeling and angioplasty- induced remodeling in an atherosclerotic yucatan micropig model. Arterioscler Thromb Vasc Biol. 1998;18:702-707

119.     Post MJ, de Smet BJ, van der Helm Y, Borst C, Kuntz RE. Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model. Circulation. 1997;96:996-1003

120.     Pasterkamp G, Wensing PJ, Hillen B, Post MJ, Mali WP, Borst C. Impact of local atherosclerotic remodeling on the calculation of percent luminal narrowing. Am J Cardiol. 1997;79:402-405

121.     Kuntz RE, Post M. Coronary remodeling and interventional strategies. Arterial Remodeling: A Critical Factor in Restenosis. 1997:471-504

122.     Doornekamp FN, Borst C, Post MJ. The influence of lesion length on intimal hyperplasia after fogarty balloon injury in the rabbit carotid artery: Role of endothelium. J Vasc Res. 1997;34:260-266

123.     de Smet BJ, Kuntz RE, van der Helm YJ, Pasterkamp G, Borst C, Post MJ. Relationship between plaque mass and neointimal hyperplasia after stent placement in yucatan micropigs. Radiology. 1997;203:484-488

124.     Dam JP, Vleeming W, Riezebos J, Post MJ, Porsius AJ, Wemer J. Effects of hypercholesterolemia on the contractions to angiotensin ii in the isolated aorta and iliac artery of the rabbit: Role of arachidonic acid metabolites. J Cardiovasc Pharmacol. 1997;30:118-123

125.     Post MJ, Pasterkamp G, Mali WP, Borst C. Computation of a location shift between two subsequent intra vascular ultrasound registrations by cross-correlation analysis of the lumen area functions. Ultrasound Med Biol. 1996;22:239-243

126.     Post MJ, de Graaf-Bos AN, van Zanten HG, de Groot PG, Sixma JJ, Borst C. Thrombogenicity of the human arterial wall after interventional thermal injury. J Vasc Res. 1996;33:156-163

127.     Post MJ, de Graaf-Bos AN, Posthuma G, de Groot PG, Sixma JJ, Borst C. Interventional thermal injury of the arterial wall: Unfolding of von willebrand factor and its increased binding to collagen after 55 degrees c heating. Thrombosis and haemostasis. 1996;75:515-519

128.     Pasterkamp G, Borst C, Post MJ, Mali WP, Wensing PJ, Gussenhoven EJ, Hillen B. Atherosclerotic arterial remodeling in the superficial femoral artery. Individual variation in local compensatory enlargement response [see comments]. Circulation. 1996;93:1818-1825

129.     Doornekamp FN, Borst C, Post MJ. Endothelial cell recoverage and intimal hyperplasia after endothelium removal with or without smooth muscle cell necrosis in the rabbit carotid artery. J Vasc Res. 1996;33:146-155

130.     Doornekamp FN, Borst C, Haudenschild CC, Post MJ. Fogarty and percutaneous transluminal coronary angioplasty balloon injury induce comparable damage to the arterial wall but lead to different healing responses. J Vasc Surg. 1996;24:843-850

131.     Post MJ, Kuntz RE, Borst C. Remodeling after ptca: From shrinkage to compensatory enlargement [letter; comment]. Circulation. 1995;92:2002-2003

132.     Post MJ, Borst C, Pasterkamp G, Haudenschild CC. Arterial remodeling in atherosclerosis and restenosis: A vague concept of a distinct phenomenon. Atherosclerosis. 1995;118 Suppl:S115-123

133.     Pasterkamp G, Wensing PJ, Post MJ, Hillen B, Mali WP, Borst C. Paradoxical arterial wall shrinkage may contribute to luminal narrowing of human atherosclerotic femoral arteries. Circulation. 1995;91:1444-1449

134.     Pasterkamp G, van der Heiden MS, Post MJ, Borst C, Gussenhoven EJ, Pieterman H, van Urk H, Bom N. Discrimination of intravascular lumen and dissections in single intravascular ultrasound images using subtraction, conventional averaging and saline flush. Ultrasound Med Biol. 1995;21:149-156

135.     Pasterkamp G, Borst C, Gussenhoven EJ, Mali WP, Post MJ, The SH, Reekers JA, van den Berg FG. Remodeling of de novo atherosclerotic lesions in femoral arteries: Impact on mechanism of balloon angioplasty. J Am Coll Cardiol. 1995;26:422-428

136.     van Erven L, Post MJ, Velema E, Borst C. In the normal rabbit femoral artery increasing arterial wall injury does not lead to increased intimal hyperplasia. J Vasc Res. 1994;31:153-162

137.     Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty. A study in the normal rabbit and the hypercholesterolemic yucatan micropig [see comments]. Circulation. 1994;89:2816-2821

138.     van Leeuwen TG, Meertens JH, Velema E, Post MJ, Borst C. Intraluminal vapor bubble induced by excimer laser pulse causes microsecond arterial dilation and invagination leading to extensive wall damage in the rabbit [see comments]. Circulation. 1993;87:1258-1263

139.     Pasterkamp G, van der Heiden MS, Post MJ, Ter Haar Romeny BM, Mali WP, Borst C. Discrimination of the intravascular lumen and dissections in a single 30-mhz us image: Use of "confounding" blood backscatter to advantage. Radiology. 1993;187:871-872

140.     Bos AN, Post MJ, de Groot PG, Sixma JJ, Borst C. Both increased and decreased platelet adhesion to thermally injured subendothelium is caused by denaturation of von willebrand factor. Circulation. 1993;88:1196-1204

141.     Borst C, van Leeuwen TG, Post MJ. In search of the optimized excimer laser angioplasty system [letter; comment]. Circulation. 1993;88:334-335

142.     van Leeuwen TG, van Erven L, Meertens JH, Motamedi M, Post MJ, Borst C. Origin of arterial wall dissections induced by pulsed excimer and mid- infrared laser ablation in the pig [see comments]. J Am Coll Cardiol. 1992;19:1610-1618

143.     van Erven L, Velema E, Bos AN, Post MJ, Borst C. Thrombogenicity and intimal hyperplasia after conventional and thermal balloon dilation in normal rabbit iliac arteries. J Vasc Res. 1992;29:426-434

144.     van Erven L, van Leeuwen TG, Post MJ, van der Veen MJ, Velema E, Borst C. Mid-infrared pulsed laser ablation of the arterial wall. Mechanical origin of "acoustic" wall damage and its effect on wall healing. J Thorac Cardiovasc Surg. 1992;104:1053-1059

145.     Smits PC, Post MJ, Velema E, Rienks R, Borst C. Percutaneous coronary and peripheral angioscopy with saline solution and carbon dioxide gas in porcine and canine arteries. American heart journal. 1991;122:1315-1322

146.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Effects of milrinone, sulmazole and theophylline on adenosine enhancement of antigen-induced bronchoconstriction and mediator release in rat isolated lungs. Pulm Pharmacol. 1991;4:239-246

147.     Post MJ, Te Biesebeek JD, Doods HN, Wemer J, Van Rooji HH, Porsius AJ. Functional characterization of the muscarinic receptor in rat lungs.Eur J Pharmacol. 1991;202:67-72

148.     Borst C, Savalle LH, Smits PC, Post MJ, Gussenhoven WJ, Bom N. Imaging of post-mortem coronary arteries by 30 mhz intravascular ultrasound. Int J Card Imaging. 1991;6:239-246

149.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Adenosine enhances antigen-induced bronchoconstriction and histamine release in rat isolated lungs. Agents Actions. 1990;30:30-33

150.     Post MJ, Moekoet C, Wemer J, van Rooij HH, Porsius AJ. Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up.Agents Actions. 1990;30:34-37

151.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Zijlstra FJ, Vermeer MA, Porsius AJ. Effects of milrinone and salbutamol on antigen induced arachidonic acid metabolism in the isolated rat lung. Biochem Pharmacol. 1989;38:2573-2574

152.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. In vivo anaphylaxis in the rat: Effects of phosphodiesterase inhibitors. Agents Actions. 1989;26:79-81

153.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Comparison of the anti-anaphylactic effects of milrinone, sulmazole and theophylline in the rat. Int Arch Allergy Appl Immunol. 1989;89:6-10

154.     Post MJ, te Biesebeek JD, van Rooij HH, Wemer J, Porsius AJ. Anti-allergic effects of milrinone and sulmazole in isolated rat lungs in comparison with theophylline. Int Arch Allergy Appl Immunol. 1989;89:1-5

155.     Post MJ, van der Weele C. Principles of tissue engineering for food. In: Lanza R, Langer R, Vacanti JP, eds. Principles of tissue engineering. Amsterdam: Elsevier; 2014:1647-1658.

156.     Post M, Ware JA. Angiogenesis in atheroclerosis and restenosis. In: Ware JA, Simons M, eds. Angiogenesis and cardiovascular disease. New York: Oxford University Press; 1999:143-158.

157.     Post M, Cornelussen R, Prinzen F. Pampering and priming the heart. In: Deindle E, Kupatt C, eds. Therapeutic neovascularization–quo vadis?Dordrecht: Springer; 2007:85-108.

158.     Simons M, Post MJ. Angiogenesis. In: Topol EJ, ed. Textbook of interventional cardiology. Philadelphia: Saunders; 2003:757-779.

159.     Simons M, Post MJ, Laham RJ, Sellke FW. Basic fibroblast growth factor trials for patients with advanced coronary disease. In: Braunwald E, ed. Harrison's advances in cardiology. New York: McGraw-Hill; 2002:248-254.

Book chapters

155-159

154.     Post MJ, van der Weele C. Principles of tissue engineering for food. In: Lanza R, Langer R, Vacanti JP, eds. Principles of tissue engineering. Amsterdam: Elsevier; 2014:1647-1658.

155.     Post M, Ware JA. Angiogenesis in atheroclerosis and restenosis. In: Ware JA, Simons M, eds. Angiogenesis and cardiovascular disease. New York: Oxford University Press; 1999:143-158.

156.     Post M, Cornelussen R, Prinzen F. Pampering and priming the heart. In: Deindle E, Kupatt C, eds. Therapeutic neovascularization–quo vadis?Dordrecht: Springer; 2007:85-108.

157.     Simons M, Post MJ. Angiogenesis. In: Topol EJ, ed. Textbook of interventional cardiology. Philadelphia: Saunders; 2003:757-779.

158.     Simons M, Post MJ, Laham RJ, Sellke FW. Basic fibroblast growth factor trials for patients with advanced coronary disease. In: Braunwald E, ed. Harrison's advances in cardiology. New York: McGraw-Hill; 2002:248-254.

 

Education

Thirty percent of my time is dedicated to teaching in Medicine and a little bit in Science. Most tasks are of an executive nature: tutoring, coaching and giving occasional lectures.

Extra Activities

no additional functions