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prof dr M.J. Post
Professor of Vascular Physiology
Chair of Physiology
My main interest is Vascular Biology, particularly fundamental processes such as vascular patterning, neovascularization, endothelial and smooth muscle cell function and restenosis. As a translational arm of the research, we develop and test novel biomaterials that are suitable for arterial grafting for bypass surgery of vascular access surgery (AV shunt), providing in situ tissue engineering. The response and in vivo remodelling of these grafts provide great insight into the role of biochemical and biomechanical cues in vascular biology.
In addition, we are engaged into early diagnosis of neovascularization by means of molecular imaging. We have identified 4 novel targets for molecular imaging that we are testing in SPECT imaging of cardiovascular models exhibiting neovascularization.
Therapeutic neovascularization will likely be dependent on effective slow release, local administration of potent biologicals. Drug release polymers are currently tested for that purpose.
Finally, I became involved in a completely different field of tissue engineering: skeletal muscle tissue engineering in order to create cultured consumption meat. This technology offers great opportunities for future meat production if culture efficiency and tissue mimicry can be achieved in a cost-effective manner.
iVALVE (PI). In this consortium we develop and test new materials for arterial grafting. It is a collaboration with TU/e, Suprapolix, SymoChem, Philips, and UMCU. We have developed an electrosensitive polymer that facilitates ingrowth, cell alignment and collagen production. We also test grafts from novel PLC-based materials in a rat aorta interposition or bypass graft model.
PENT (PI). In this consortium together with TU/e, DSM, UMUC and LUMC, we develop and tested novel agent and delivery methods to enhance neovascularization.
TeRM (PI). TeRM is a national consortium of several universities and companies with the aim to develop novel tissue engineering solutions for musculoskeletal and cardiovascular defects. Autologous cells on biomaterials are being used for this purpose. Our group tested grafts in large and small animal models of interposition grafts and AV shunts. In addition, we developed novel assays for thrombogenicity of endothelial layers and on-line non-destructive collagen synthesis. Smooth muscle cell thrombogenicity and smooth muscle cell relaxation in the setting of uremia are also being investigated
EMINENCE (coordinator/PI). This is also a national consortium focussing on early diagnosis of neovascularization using sophisticated MRI acquisition and image analysis, but also novel molecular targets and visualization with SPECT.
The Hamburger project is a philantropy financed program which aims to develop consumption meat from bovine skeletal muscle stem cells. In the spring of 2013 we plan to present the world's first labgrown hamburger.
Thirty percent of my time is dedicated to teaching in Medicine and a little bit in Science. Most tasks are of an executive nature: tutoring, coaching and giving occasional lectures.